1. TEM1-targeting PEGylated PLGA shikonin nanoformulation for immunomodulation and eradication of ovarian cancer

Efthymia-Iliana Matthaiou , Yi Guo, Jaleh Barar , Raphael Sandaltzopoulos, Lana E. Kandalaft, Chunsheng Li*, George Coukos, Yadollah Omidi*

Bioimpacts. 2022;12(1): 65-86. doi: 10.34172/bi.2021.23511

PMCID: PMC8783079 PMID: 35087718 Scopus ID: 85127176631

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Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) functionalized with polyethylene glycol (PEG)and anti-TEM1 antibody fragment (78Fc) and loaded with necrosis-inducing agent shikonin (SHK)(78Fc-PLGA-SHK NPs) is a highly effective immunostimulating nanomedicine against theTEM1-expressing cells for targeted therapy of solid tumors.

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